Endocrine Abstracts

Background: Hashimoto’s thyroiditis is the most common autoimmune endocrine disorders and often leads to hypothyroidism. There is a relation with Vitamin D levels, vitamin D receptor (VDR) and HT reported. More than 30 gene polymorphisms are found in VDR gene. The most common four types of polymorphisms studied in autoimmune disease are FokI (exon 2), BsmI (intron 8), ApaI (intron 8) and TaqI (exon 9). The aim of this study is to investigate the association between VDR Fo...

Te paraneoplastic Cushing’s syndrome represents 9 to 18% of ACTH-dependent endogenous hypercorticisms; which poses, in clinical practice, two types of problems:– on the one hand, the differential diagnosis with Cushing’s disease, when well differentiated and morphologically undetectable endocrine tumors are involved.– on the other hand, the control of hypercortism, most often major in metastatic neuroendocri...

Gitelman’s syndrome (GS) is an autosomal recessive primary renal tubular disorder with hypokalemic metabolic alkalosis, hypocalciuria, and magnesium deficiency. The association of GS and type 1 diabetes is rare1, and bilateral hydronephrosis and hydroureter has not been reported.A 18-year-old female with known GS diagnosed at 17 years of age and type 1 diabetes diagnosed at 15 years of age was admitted to Leicester Royal Infirmary for pre...

A 60-year-old Caucasian male was referred to our Endocrine unit with symptoms suggestive of adrenal failure (malaise and fatigue).A Synachten test confirmed the diagnosis (baseline cortisol <5 nmol/l, post Synachten 74 nmol/l) and indicated secondary adrenal failure (baseline ACTH undetectable). Further hormonal tests showed secondary hypothyroidism (TSH 0.43 mU/ml, FT4 7.1 pmol/l) and hypogonadism (testosterone <0.7 nmol/l, LH 0.6 U/l). Prolacti...

IntroductionCushing’s disease described in 1973 by Harvey Cushing is the most frequent cause of endogenous hypercorticism in adults in 80-85% of cases of Cushing’s syndromes, it is secondary to a pituitary microadenoma most often, its treatment is first-line neurosurgical.Aim of the studyTo evaluate the results of the short and medium term therapeutic management of Cushing’s disease and to try ...

We are reporting a rare case of ectopic ACTH secreting tumour causing cyclical Cushing’s syndrome. A 63-year-old lady presented in March 2013 with tiredness and bilateral leg swelling and weakness associated with easy bruising. She was admitted to local hospital in April 2013 with worsening proximal myopathy and peripheral oedema. Her midnight cortisol was elevated at 1710 nmol/l. ACTH 610 mU/l, prolactin 476 mU/l, GH 0.21 IU/l, TSH 0.73 mU/l, free T4 of 11.0 p...

Introduction: Cushing’s syndrome (CS) secondary to ectopic adrenocorticotrophic hormone (ACTH)–producing prostate cancer is rare with less than 30 cases reported. We report a case of Cushing’s syndrome secondary to prostate adenocarcinoma with recurrent hypokalemia, sepsis and rapid disease progression. A 61-year-old man presented in January 2019 with 3-week history of lower limb swelling and weakness. Past medical history is significant for metastatic prosta...

Introduction: Cushing’s syndrome is associated with significant chronic and acute complications including acute thromboembolic and cardiovascular events. We aimed to study the prevalence and predictors of acute and perioperative complications in patients with active Cushing’s syndrome.Methods: The prevalence, predictors and outcomes of acute, life-threatening and perioperative complications were evaluated in a cohort of patients with active b...

We evaluate the short and long-term outcomes following diagnosis and treatment of pituitary dependent Cushing’s disease from a single centre. From 1971, there were 47 patients with proven endogenous cortisol excess, of whom, 43 (92%) had pituitary dependent Cushing’s disease. The median age of this cohort was 38±11years and the majority (77%) were females. 17 patients had primary treatment either with radiotherapy (n=9), bilateral adrenalectomy (n=...

Decreased bone mineral density (BMD) and disturbances in glucose metabolism are common complications of Cushing’s disease. Many recent studies have shown that hyperinsulinemia in type 2 diabetes mellitus (DM) may lead to higher BMD as compared to healthy individuals. The aim of the present study was to investigate the possible relationships between BMD, serum markers of bone metabolism and plasma cortisol concentrations. The second objective was to determine whether the p...